Curth-Macklin Ichthyosis Hystrix of Curth-Macklin
نویسندگان
چکیده
Ichthyosis hystrix of Curth-Macklin ( IHCM) is an extremely rare keratinization disorder, with verrucous to hystrixlike hyperkeratotic plaques of varying extent. The diagnosis is based on a distinctive pattern of epidermolytic hyperkeratosis and the presence of binucleate cells under light microscopy, as well as unique electron microscopic findings of continuous perinuclear tonofibril shells in the suprabasal keratinocytes. We present the clinical manifestation and light and electron microscopic findings in a 23-year old male patient with IHCM. (Dermatol Sinica 22 : 239-242, 2004)
منابع مشابه
Helen Ollendorff Curth and Curth-Macklin Syndrome
Helen Ollendorff Curth (1899-1982), is one of the pioneers in dermatology. In 1954, she and Madge Thurlow Macklin (1893–1962), an American medical geneticist, reported, a rare congenital genodermatosis that was later known as Curth-Macklin syndrome. This syndrome is a rare autosomal dominant skin disorder characterized by extensive hyperkeratosis and palmo-plantar keratoderma. This report shed ...
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